Epiphyllum sp. (orchid cactus) with oedema - an abiotic problem where subepidermal cells expand and protrude through the leaf surface.
OSU Plant Clinic image, 2010.
See:
Orchid - Bacterial Brown Spot
Note: There are many fungal and bacterial leaf spots of orchid but samples sent to the OSU Plant Clinic have mostly had abiotic brown leaf spots.